（１）Oxidative damage
About 21 % of air is occupied by oxygen which brings every life form, either plant or animal, to oxidative damage more or less, which could be said to be a kind of fate for it.
（２）Production of active oxygens
At the same time, we are maintaining metabolism using oxygen taken by lungs by oxidizing food taken by mouth, which brings inevitably production of active oxygen species as a result.
In summary, we should keep in mind that we are always under the risk of oxidative damage, both externally and internally.

（１）Characteristic of water on the earth
The existence of water on the earth has made it possible for living organisms to be born and exist there.
It should be noticed that the reality of water on the earth has a common feature, namely water hardly contains hydrogen gas because of its character of being the lightest and the smallest element which results in rapid disappearing. Such kind of water could be called 'hydrogen-deleted or hydrogen-poor water'.
（２）Imperfection of 'hydrogen-deleted water'
It could be postulated that life forms born in hydrogen-poor water should have faced the fatal risk, which forced them to develop a measure to fight against oxidative damage, namely antioxidative enzyme.
（３）Hydrogenase
A very important and interesting paper was submitted by R.P.Happe in 'Nature', 385, 126, '97. He says, the oldest life forms 'Desulfovibrio gigas (3.8 billion years old)', had developed an enzyme hydrogenase to activate hydrogen, namely to split molecular hydrogen to atomic or active hydrogen.

（１）Temporary hydrogen-enriched water
In Japan we have water treatment devices to reform water by way of electrolysis. Electrolysis of water produces anodic water with increased oxygen content, and cathodic water with increased hydrogen content which diminishes, however, rapidly because of nature of hydrogen itself.
（２）Constant hydrogen-enriched water
In March 2001 cathodic water has been confirmed to lose its increased hydrogen gas in the first several minutes.
So that cathodic water should be called 'temporary hydrogen-rich water'. A new approach was therefore necessary to cover the shortage of cathodic or temporary hydrogen-rich water.
The new procedure developed by us is based on the following chemical formula, in which hydrogen gas can be produced when magnesium pellet is thrown into water.

Ｍｇ

＋

２Ｈ2Ｏ

→

Ｍｇ（ＯＨ）2

＋

Ｈ2   ↑

When HPM(Hydrogen Producing Mineral)stick is put into water in the bottle, hydrogen content can be confirmed to increase up to saturated level only in the first 10 to 20 minutes.
It has become possible now to obtain constant hydrogen-rich water very easily, reliably and with minimum cost( Table 1).
We have observed clinical improvements obtained from intake of hydrogen-rich water, cathodic water at the beginning and later HPM-stick water, as shown below.

（１）Water Regulating Theory (Hayashi's Model)
Molecular hydrogen in our drinking water, when taken into our body, should be splitted to atomic or active hydrogen by help of hydrogenase which should reduce active oxygens resulting in production of H₂O.

（１）	Ｏ2	＋	ｅ-			→	Ｏ2-
（２）	Ｏ2-	＋	Ｈ	＋	Ｈ+	→	Ｈ2Ｏ2
（３）	Ｈ2Ｏ2	＋	ｅ-			→	ＨＯ・	＋	ＨＯ-
（４）	ＨＯ・	＋	Ｈ			→	Ｈ2Ｏ
（５）	ＨＯ-	＋	Ｈ+			→	Ｈ2Ｏ

Disease should originally be defined to be contradiction for every living organism, which lives on the principle of living organism, self and family maintenance along with evolution. Why then, has such a big contradiction been disregarded for such a long time, namely since the birth of human medicine? The answer for it should be in water, on which all life forms have been dependent; water poor in hydrogen, and hence being insufficient to reduce or scavenge active oxygen species.
In other words, if they might depend on hydrogen-rich water in their daily lives, they might fulfill health and longevity relatively easily, which means contradiction for them can be conquested in a future, so is my theory and belief.